SALT COMPOSITION: Glimepiride + Metformin + Pioglitazone

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  • This medicine is a combination of three drugs Glimepiride, Metformin and Pioglitazone, which collectively controls High sugar level in a diabetic person suffering from Type 2 Diabetes Mellitus and belongs to a class of medicine known as anti-diabetic drugs.
  • Glimepiride is a sulfonylurea which controls your blood sugar level along with Metformin which is a Biguanide and Pioglitazone which is a Thiazolidinedione Derivative.
  • Glimepiride content of this medicine works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.
  • Metformin content of this medicine is a first line drug for treatment of Type 2 Diabetes Mellitus, Especially for people who are overweight.
  • Pioglitazone is a Thiazolidinedione (PPAR Gamma Agonist) which should be used along with a proper diet and exercise program to control high blood glucose level.
  • In brief, these three drugs work with each other in different ways to prevent the blood glucose levels from rising to very high levels thus keeping your Diabetes under control.
  • This medicine is not recommended for people with Type 1 Diabetes or if you have ketoacidosis or if you have severe kidney and liver disease. Please consult your doctor. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.


  • Management of Type 2 Diabetes Mellitus


In Type 2 Diabetes Mellitus:
  • This medicine is combination of three different drugs that works collectively in different ways to help you in controlling your blood sugar level. Controlling blood sugar level is an important part of managing diabetes.
  • By controlling blood sugar level this medicine helps you to prevent any future serious complications arises due to uncontrolled diabetes like kidney damage, heart damage, liver damage, nerve damage, eye sight damage and other vital organs damage.
  • Taking this medicine regularly along with following a proper diet chart and exercise will help you live a normal, healthy life.

Adverse Effects

Most adverse effects do not require any medical attention and disappear as soon as your body adjusts to the medicine. Consult your doctor if they persist for longer duration or if causes any serious trouble.

Common Adverse Effects:
  • Bone fracture
  • Dizziness
  • Fatigue
  • Headache
  • Hypoglycemia (Low Blood Glucose Level)
  • Loss of Appetite
  • Nausea
  • Tremor
  • Taste alteration
  • Weakness
  • Weight gain

How To Use?

  • You can take this medicine in the dose and duration as advised by your doctor. It should be taken with food at fixed time every day.
  • please do not try to cut or break the medicine with knife or by any other means. please take it as a whole and swallow with water.

Drug Working Mechanism

  • This medicine is combination of three different drugs Glimepiride (a Sulfonylurea) along with Metformin (a Biguanide) and Pioglitazone (a Thiazolidinedione Derivative).
  • Glimepiride content of this medicine works by increasing the amount of insulin released by the pancreas.
  • Metformin content of this medicine works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body’s response to insulin.
  • Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enable cells to remove glucose from blood more effectively.
  • Thus different ingredients of this medicine works with each other to effectively control your blood sugar at desired level.


 Alcohol Unsafe

You are recommended to avoid alcohol consumption with this medicine as it may dangerously alter your blood sugar level. Taking alcohol with this medicine can also lead to a rare but life-threatening condition known as Lactic Acidosis.

 Pregnancy Expert Consultation Required

It is better to avoid this drug during pregnancy. Although there are limited studies in humans, animal studies shows harmful effects on the developing baby. your doctor may prescribe this medicine after weighing the benefits and any potential risk during pregnancy.

 Breast Feeding Safe If Prescribed

This medicine is probably safe to use during breastfeeding as limited available human data suggests that it does not represent any significant risk to the majority of babies. However there are some available data also suggest that this medicine may be excreted in breastmilk and cause adverse effects in few babies, So Monitor the breastfed baby’s blood sugar during treatment with This medicine.

 Driving May Be Unsafe

This medicine may trigger hypoglycemic events in few situations with decreased alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

 Kidney Caution

This medicine should be used with caution in patients suffering from kidney disorders. Dose adjustment may be needed for these patients. however it is not recommended to use this medicine for patients suffering from severe kidney diseases. Regular monitoring of kidney function test is advisable while you are taking this medicine. Please take an expert advice.

 Liver Caution

This medicine should be used with caution in patients suffering from Liver diseases. Dose adjustment is necessary for these patients. Regular monitoring of Liver function is also necessary for these patients. Use of this medicine is not advised in patients with severe Liver disease until it becomes extreme necessary.

Missed Dose

If you miss a dose of this medicine, please take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and adhere on your regular schedule. Do not double the dose for adjusting the missed dose at very short interval.

Drug Interactions

Tell your physician if you are taking or have recently taken any other medicines, herbal preparations, including medicines obtained without prescription because taking this medicine with any of these can modify the effect of either of them and cause some serious side effects:

  • Allopurinol, probenecid, sulfinpyrazone, (Used to treat gout)
  • ACE Inhibitors (Used to treat High BP)
  • Acetazolamide (Used to treat increased pressure in the eye)
  • Beta-blockers, clonidine, guanethidine and reserpine (Used to treat high blood pressure or heart failure)
  • Coumarin derivatives such as warfarin
  • Chlorpromazine and other phenothiazine derivatives (Used to treat severe mental disorders)
  • Disopyramide called anti-arrhythmic agents (Used to control abnormal heart beat)
  • Fenfluramine (Used to reduce weight)
  • Fibrates (Used to lowering high cholesterol level)
  • Fluoxetine, MAO inhibitors (Used to treat depression)
  • H2 Antagonists (Used to treat Gastric ulcers)
  • Levothyroxine, (Used to stimulate the thyroid gland)
  • Laxatives (Used to treat constipation) when they are used for long term
  • Oestrogens, progestogens (female sex hormones)
  • Phenytoin (Used to treat Seizures)
  • Phenylbutazone, azopropazone, oxyphenbutazone, aspirin (Used to treat pain and inflammation)
  • Rifampicin (used to treat tuberculosis and other infections)
  •  sulfonamides (Used to treat urinary infections)
  • Tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin (Used to treat Bacterial and fungal infections)

Drug Info Box

  • Habit Forming No
  • Therapeutic class Anti-Diabetic Medicine

Beneficial Tips

  • Take this medicine at same time everyday for effective management of your blood sugar level.
  • Hypoglycemic events may occur, if you are taking this medicine with few other anti-diabetic medicine or with alcohol consumption or forget to take a meal.
  • It is advised to carry few sugar candy with you. In case of hypoglycemic events you can consume it. Cold sweats, cool pale skin, tremor, anxiety etc. are few common symptoms of hypoglycemia.
  • Do regular exercise and take healthy meal with diet planning is advisable to effectively control your blood sugar level along with this medicine.
  • Always inform your doctor about your all prescription as well as herbal preparation medicines, before using this medicine.


  • Store in a cool and dry place below 30°C away from direct sunlight.
  • Keep away from the reach of children.


  1. Glimepiride. North Harrow, Middlesex: Accord Healthcare Limited; 2008 [revised 24 Jul. 2014]. [Accessed 24 Aug. 2021] (online) Available from:External Link
  2. Metformin hydrochloride oral solution. Gloversville, New York: Ranbaxy Pharmaceuticals Inc.; 2003. [Accessed 24 Aug. 2021] (online) Available from:External Link
  3. Pioglitazone hydrochloride. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2000 [revised 13 Sep. 2018]. [Accessed 24 Aug. 2021] (online) Available from:External Link

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What is Glimepiride with metformin and Pioglitazone combination medicine?

Glimepiride with metformin and Pioglitazone are combination of drugs used in the management of Type 2 Diabetes Mellitus. These drugs work together to control your blood sugar at desired level.

Is it always safe to take this medicine?

Your doctor have prescribed this medicine because he weighs the benefits of taking this medicine is more than minor side effects of the medicine, so please follow your doctor’s advice.

What are the special cautions while taking this medicine?

The use of this medicine is considered to be harmful if you are allergic to any ingredients of the medicine. Please also inform your doctor about your current health condition like any existing diseases, pregnancy, any drug allergy etc.

How to take this medicine?

You can take this medicine with or without food preferably at the fixed time everyday as advised by your doctor.

What to do if I forget to eat the medicine?

If you missed the dose of this medicine, please take it as soon as possible, but if it is almost the time for the next dose, please skip it and continue with the next dose. don’t try to take the missed dose of medicine at very short interval.

what to do in case of allergic reaction from the medicine?

If you experienced any kind of allergic reaction from the medicine, please consult your physician as soon as possible. Your physicians are able to manage the case according to severity of the allergic reaction. Sometimes allergy will be minor and don’t require any specific management but in case of severe hypersensitivity reactions you need some interventions from your physician.

Can I stop taking the medicine when my symptoms disappears?

Please consume the complete dose of the medicine as prescribed by your doctor. even if you are feeling well, it is always beneficial to complete the whole dose of medicines.

Can I take a higher than the recommended dose of medicine?

Please don’t consume the medicine more than the recommended dose. It may be harmful for you. It may also increases your chances for causing serious side effects.

What to do if my symptoms are not improving even after taking the medicine?

If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation. Don’t take more than the recommended dose of medicine for immediate relief from the symptoms.

What are the doses for this medicine?

Please follow the instructions received by your doctor for the exact dose of this medicine. The exact dose of this medicine varies for person to person depending on many factors like patient’s age, weight and many more so it is better to follow your doctor’s advice. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor.

What is Type 2 Diabetes?

  • Type 2 Diabetes is a chronic condition (long lasting) and it is an impairment in the way the body regulates and uses sugar (glucose) as a fuel.
  • Pancreas of peoples suffering from Type 2 Diabetes do not produce enough insulin or their body cells develop insulin resistance.

What are the signs and symptoms of Type 2 Diabetes?

Increased blood sugar level, Frequent urination, increased thrust and increased hunger are few common signs and symptoms of Type 2 Diabetes.

What is Insulin Resistance?

Insulin resistance is a condition when your body cells don’t respond well to insulin and can’t easily take up glucose from your blood. As a result, your pancreas makes more insulin to help glucose to enter in your cells.

What is Hypoglycemic event?

Hypoglycemic events also called hypoglycemia is a condition when your blood sugar level falls below the recommended level and causes headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious.

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Additional information

Weight 5 g
Dimensions 6 × 4 × 2 cm

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