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Amfirst 2.5mg Tablet 10???s

SALT COMPOSITION: Amlodipine Besylate


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Description

Introduction

  • This medicine contains Amlodipine Besylate as an active Ingredient. Amlodipine Besylate belongs to a class of drugs known as Calcium Channel Blockers.
  • Calcium Channel Blockers (CCBs) are a class of first line antihypertensive drugs.
  • They Lower BP (Blood Pressure) by decreasing peripheral resistance without compromising cardiac output. Despite vasodilation, fluid retention is insignificant.
  • Thus amlodipine besylate lowers blood pressure and reduce the heart’s workload, which helps to prevent heart attacks and strokes.

Dose

  • Amlodipine may be prescribed separately or along with other medications. The dose depends on the condition for which you are taking this medicine. The dose also depends on the severity of your condition.
  • It’s usual to take this medicine once a day.
  • You can take Amlodipine at any time of the day, with or without food, but try to make sure it’s around the same time each day.

Duration

  • You should take this medicine for as long as your doctor has prescribed for you.
  • Even if you feel better, still do not stop this medicine without your physician’s advice. Always remember high blood pressure often shows no symptoms but high BP is a silent killer.
  • If you suddenly stop taking this medicine, your health condition may get worsen.

Uses

  • Management of High Blood Pressure
  • Prevention of Angina (Heart Related Chest Pain)

Benefits

In Hypertension (HIGH BP):
  • This medicine lowers your blood pressure by decreasing peripheral resistance through relaxing the blood vessels and makes it easier for your heart to pump blood around your body.
  • Thus this medicine also reduces your risk of having a stroke, a heart attack or kidney problems in the future. If you are taking this medicine regularly, it works in the long term to keep you well.
In Prevention Of Angina:
  • Angina is a chest pain that starts when not enough blood supply goes to the muscles of the heart due to narrowing of the coronary arteries that supplies blood to the muscles of the heart. These coronary arteries are responsible for transportation of oxygenated blood to the heart muscles.
  • This tablet widens the coronary arteries and thus improving the oxygenated blood supply to the heart muscles, so chest pain is prevented

Adverse Effects

Most adverse effects do not require any medical attention and disappear as soon as your body adjusts to the medicine. Consult your doctor if they persist for longer duration or if causes any serious trouble.

Common Adverse Effects:
  • Headache
  • Fatigue
  • Nausea
  • Abdominal Pain
  • Sleepiness
  • A Pounding Heart beat
  • Swollen Ankles
  • Postural Dizziness.

Drug Working Mechanism

  • This tablet contains amlodipine, which is a calcium channel blocker.
  • Like other calcium channel blockers, It works in high blood pressure by relaxing and widening peripheral blood vessels.
  • Thus it works by decreasing peripheral resistance of blood vessels.
  • In angina this tablet increases oxygenated blood supply to the heart by widening the arteries.

Precautions

 Alcohol Caution

Please be cautious while consuming this medicine along with alcohol. Alternatively you can also take an expert advice for the same with your doctor.

 Pregnancy Expert consultation required

  • FDA categorizes all the medicines on the basis of safety for use during pregnancy in 5 classes A B C D and X.
  • This tablet falls in category C of FDA Classification, which means there are no good studies available for uses during pregnancy.
  • Please stick on your doctor’s advice for use of this medicine during pregnancy.

 Breast Feeding Safe if Prescribed

Inform your doctor if you are breast feeding mom. it is not known if amlodipine is excreted in human breast milk. Limited human data suggests that the drug does not represent any significant risk to the baby.

 Driving UnsafeThis tablet may affect your ability to drive or use machines. If the tablet make you feel sick, dizzy or tired, or give you a headache, Please Do not drive or operate machineries and consult your doctor.

 Kidney Safe if Prescribed

This Medicine is safe to use for patients suffering from kidney disorders. Usually there is no need to adjust the dose of this medicine for these patients.

 Liver Caution

All the calcium channel blockers including this tablet are extensively metabolized by your Liver. If your Liver is not working well, it causes accumulation of this drug inside your body for more than recommended dose and duration, so dose adjustment may be needed for such patients. Please consult your doctor.

Missed Dose

If you miss a dose of this medicine, please take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and adhere on your regular schedule. Do not double the dose for adjusting the missed dose at very short interval.

Drug Interactions

Taking this tablet along with any of  the below mentioned medicines can alter the effect of both medications and causes some side effects.

  • Any other hypertensives
  • Verapamil, Diltiazem
  • Ketoconazole and itraconazole (used to treat fungal infections)
  • Ritonavir
  • Clarithromycin, erythromycin and telithromycin, rifampicin, rifabutin (antibiotics)
  • Nefazodone (used to treat depression)
  • Dexamethasone (used to treat inflammatory and autoimmune conditions)
  • Dantrolene
  • Simvastatin (cholesterol lowering medicine)
  • Cyclosporine, tacrolimus (immunosuppressant)
  • Phenobarbital, phenytoin and carbamazepine (used for epilepsy)
  • Sildenafil (used for impotence)

Drug Info Box

  • Chemical Class Dihydropyridines
  • Habit Forming No
  • Therapeutic Class Hypertensive Drugs
  • Action Class Calcium channel blockers- Dihydropyridines (DHP)

Beneficial Tips

  • Take this tablet at same time everyday for effective management of your blood pressure.
  • Initially when you start taking this tablet, it can suddenly drop your BP. To reduce the chance of feeling dizzy or passing out, you should change your position slowly from sitting or lying down to standing position.
  • Raise your legs while you are sitting down. This way you can reduce the ankle or foot swelling caused by side effects due to this medicine.
  • Always inform your doctor about your all prescription as well as herbal preparations, before using this medicine.

Storage

  • Store in a cool and dry place away from direct sunlight.
  • Keep away from the reach of children.

References

  1. Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 758-60.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 60-61.
  3. Opie LH. Calcium Channel Blockers. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 86-88.
  4. Amlodipine besylate [FDA Label]. New York, NY: Pfizer; 2011. [Accessed 25 June 2021] (online) Available from:External Link
  5. Amlodipine besylate [FDA Label]. New York, NY: Pfizer Labs.; 1987 [revised May 2011]. [Accessed 26 June 2021] (online) Available from:External Link
  6. Drugs.com. Amlodipine Pregnancy and Breastfeeding Warnings. [Accessed 26 June 2021] (online) Available from:External Link
  7. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amlodipine. [Updated 2018 Dec 3]. [Accessed 26 June 2021] (online) Available from:External Link
  8. Central Drugs Standard Control Organisation (CDSCO). Amlodipine. [Accessed 26 June 2021] (online) Available from:External Link
  9. KD Tripathi MD. Anti-anginal and other anti-ischaemic drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 549.

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FAQs

What is the Amlodipine Besylate

Amlodipine besylate is an antihypertensive drug used to manage the high blood pressure of a person. It is also used in the management of angina which is a heart related pain due to reduced oxygenated blood supply to the muscles of the heart.

Is it always safe to take this medicine?

Your doctor have prescribed this medicine because he weighs the benefits of taking this medicine is more than minor side effects of the medicine, so please follow your doctor’s advice.

What are the special cautions while taking this medicine?

The use of this medicine is considered to be harmful if you are allergic to any ingredients of the medicine. Please also inform your doctor about your current health condition like any existing diseases, pregnancy, any drug allergy etc.

How to take this medicine?

You can take this medicine with or without food preferably at the same time everyday.

What to do if I forget to eat the medicine?

If you missed the dose of this medicine, please take it as soon as possible, but if it is almost the time for the next dose, please skip it and continue with the next dose. don’t try to take the missed dose of medicine at very short interval.

what to do in case of allergic reaction from the medicine?

If you experienced any kind of allergic reaction from the medicine, please consult your physician as soon as possible. Your physicians are able to manage the case according to severity of the allergic reaction. Sometimes allergy will be minor and don’t require any specific management but in case of severe hypersensitivity reactions you need some interventions from your physician.

Can I stop taking the medicine when my symptoms disappears?

Please consume the complete dose of the medicine as prescribed by your doctor. even if you are feeling well, it is always beneficial to complete the whole dose of medicines.

Can I take a higher than the recommended dose of medicine?

Please don’t consume the medicine more than the recommended dose. It may be harmful for you. It may also increases your chances for causing serious side effects.

What to do if my symptoms are not improving even after taking the medicine?

If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation. Don’t take more than the recommended dose of medicine for immediate relief from the symptoms.

What is the dose for this medicine?

Please follow the instructions received by your doctor for the exact dose of this medicine. The exact dose of this medicine varies for person to person depending on many factors like patient’s age, weight and many more so it is better to follow your doctor’s advice. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor.

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Additional information

Weight 5 g
Dimensions 6 × 4 × 2 cm

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