- This medicine is a combination of two drugs Glimepiride and Metformin, which controls High sugar level in a diabetic person suffering from Type 2 Diabetes Mellitus and belongs to a class of medicine known as anti-diabetic drugs.
- Glimepiride is a sulfonylurea which controls your blood sugar level along with Metformin which is a Biguanide.
- In brief, these two drugs work together to prevent the blood glucose levels from rising to very high levels thus keeping your Diabetes under control.
- Metformin content of this medicine is a first line drug for treatment of Type 2 Diabetes Mellitus, Especially for people who are overweight.
- This medicine is not recommended for people with Type 1 Diabetes or if you have ketoacidosis or if you have severe kidney and liver disease. Please consult your doctor. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
Management of Type 2 Diabetes Mellitus
In Type 2 Diabetes Mellitus:
- This medicine is combination of two different drugs that works collectively in different ways to help you in controlling your blood sugar level without any weight gain. Controlling blood sugar level is an important part of managing diabetes.
- By controlling blood sugar level this medicine helps you to prevent any future serious complications arises due to uncontrolled diabetes like kidney damage, heart damage, liver damage, nerve damage, eye sight damage and other vital organ damage.
- Taking this medicine regularly along with following a proper diet chart and exercise will help you live a normal, healthy life.
Most adverse effects do not require any medical attention and disappear as soon as your body adjusts to the medicine. Consult your doctor if they persist for longer duration or if causes any serious trouble.
Common Adverse Effects:
- Hypoglycemia (Low Blood Glucose Level)
- Loss of Appetite
- Taste alteration
- You can take this medicine in the dose and duration as advised by your doctor. It should be taken with food at fixed time every day.
- please do not try to cut or break the medicine with knife or by any other means. please take it as a whole and swallow with water.
- This medicine is combination of two drugs Glimepiride (a Sulfonylurea) along with Metformin (a Biguanide). They works together to effectively control your blood sugar at optimal level.
- Glimepiride content of this medicine works by increasing the amount of insulin released by the pancreas.
- Metformin content of this medicine works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body’s response to insulin.
You are recommended to avoid alcohol consumption with this medicine as it may dangerously alter your blood sugar level. Taking alcohol with this medicine can also lead to a rare but life-threatening condition known as Lactic Acidosis.
Pregnancy Expert Consultation Required
It is better to avoid this drug during pregnancy. Although there are limited studies in humans, animal studies shows harmful effects on the developing baby. your doctor may prescribe this medicine after weighing the benefits and any potential risk during pregnancy.
Breast Feeding Safe If Prescribed
This medicine is probably safe to use during breastfeeding as limited available human data suggests that it does not represent any significant risk to the baby.
Driving May Be Unsafe
This medicine may trigger hypoglycemic events in few situations with decreased alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
This medicine should be used with caution in patients suffering from kidney disorders. Dose adjustment may be needed for these patients. however it is not recommended to use this medicine for patients suffering from severe kidney diseases. Regular monitoring of kidney function test is advisable while you are taking this medicine. Please take an expert advice.
This medicine should be used with caution in patients suffering from Liver diseases. Dose adjustment is necessary for these patients. Regular monitoring of Liver function is also necessary for these patients. Use of this medicine is not advised in patients with severe Liver disease until it becomes extreme necessary.
If you miss a dose of this medicine, please take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and adhere on your regular schedule. Do not double the dose for adjusting the missed dose at very short interval.
Tell your physician if you are taking or have recently taken any other medicines, herbal preparations, including medicines obtained without prescription because taking this medicine with any of these can modify the effect of either of them and cause some serious side effects:
- Digoxin (Heart failure medicine)
- Furosemide (Diuretic pill)
- Hydrochlorothiazide and amlodipine (High BP pills)
- Metoprolol (High BP Pills)
- Prednisolone (Steroids)
Habit Forming No
Therapeutic class Anti-Diabetic Medicine
- Take this medicine at same time everyday for effective management of your blood sugar level.
- Hypoglycemic events may occur, if you are taking this medicine with few other anti-diabetic medicine or with alcohol consumption or forget to take a meal.
- It is advised to carry few sugar candy with you. In case of hypoglycemic events you can consume it. Cold sweats, cool pale skin, tremor, anxiety etc. are few common symptoms of hypoglycemia.
- Do regular exercise and take healthy meal with diet planning is advisable to effectively control your blood sugar level along with this medicine.
- Always inform your doctor about your all prescription as well as herbal preparation medicines, before using this medicine.
- Store in a cool and dry place below 30°C away from direct sunlight.
- Keep away from the reach of children.
- Metformin Hydrochloride Prolonged Release & Glimepiride Tablets I.P. Ankleshwar: Sanofi India Limited; 2018. [Accessed 24 Aug. 2021] (online) Available from:
- Glimepiride. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC.; 2009. [Accessed 24 Aug. 2021] (online) Available from:
- Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 24 Aug. 2021] (online) Available from:
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What is Glimepiride with metformin medicine?
Glimepiride with metformin is a combination of drugs used in the management of Type 2 Diabetes Mellitus. These drugs work together to control your blood sugar at desired level.
Is it always safe to take this medicine?
Your doctor have prescribed this medicine because he weighs the benefits of taking this medicine is more than minor side effects of the medicine, so please follow your doctor’s advice.
What are the special cautions while taking this medicine?
The use of this medicine is considered to be harmful if you are allergic to any ingredients of the medicine. Please also inform your doctor about your current health condition like any existing diseases, pregnancy, any drug allergy etc.
How to take this medicine?
You can take this medicine with or without food preferably at the fixed time everyday as advised by your doctor.
What to do if I forget to eat the medicine?
If you missed the dose of this medicine, please take it as soon as possible, but if it is almost the time for the next dose, please skip it and continue with the next dose. don’t try to take the missed dose of medicine at very short interval.
what to do in case of allergic reaction from the medicine?
If you experienced any kind of allergic reaction from the medicine, please consult your physician as soon as possible. Your physicians are able to manage the case according to severity of the allergic reaction. Sometimes allergy will be minor and don’t require any specific management but in case of severe hypersensitivity reactions you need some interventions from your physician.
Can I stop taking the medicine when my symptoms disappears?
Please consume the complete dose of the medicine as prescribed by your doctor. even if you are feeling well, it is always beneficial to complete the whole dose of medicines.
Can I take a higher than the recommended dose of medicine?
Please don’t consume the medicine more than the recommended dose. It may be harmful for you. It may also increases your chances for causing serious side effects.
What to do if my symptoms are not improving even after taking the medicine?
If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation. Don’t take more than the recommended dose of medicine for immediate relief from the symptoms.
What are the doses for this medicine?
Please follow the instructions received by your doctor for the exact dose of this medicine. The exact dose of this medicine varies for person to person depending on many factors like patient’s age, weight and many more so it is better to follow your doctor’s advice. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor.
What is Type 2 Diabetes?
- Type 2 Diabetes is a chronic condition (long lasting) and it is an impairment in the way the body regulates and uses sugar (glucose) as a fuel.
- Pancreas of peoples suffering from Type 2 Diabetes do not produce enough insulin or their body cells develop insulin resistance.
What are the signs and symptoms of Type 2 Diabetes?
Increased blood sugar level, Frequent urination, increased thrust and increased hunger are few common signs and symptoms of Type 2 Diabetes.
What is Insulin Resistance?
Insulin resistance is a condition when your body cells don’t respond well to insulin and can’t easily take up glucose from your blood. As a result, your pancreas makes more insulin to help glucose to enter in your cells.
What is Hypoglycemic event?
Hypoglycemic events also called hypoglycemia is a condition when your blood sugar level falls below the recommended level and causes headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious.